Cardiovascular events in patients undergoing hip fracture surgery treated with remote ischaemic preconditioning: 1‐year follow‐up of a randomised clinical trial

Remote ischaemic preconditioning reduces the risk of myocardial injury within 4 days hip fracture surgery. We aimed to investigate effect remote on incidence major adverse cardiovascular events 1 year after performed a phase-2, multicentre, randomised, observer-blinded, clinical trial between February 2015 and September 2017. studied patients aged ≥ 45 years with minimum one factor. Patients were allocated randomly applied just before surgery or no treatment (control group). was upper arm tourniquet in four cycles 5 min ischaemia reperfusion. Primary outcome occurrence A total 316 group 309 control group. Major occurred 43 (13.6%) compared 51 (16.5%) (adjusted hazard ratio (95%CI) 0.83 (0.55–1.25); p = 0.37). Fewer had infarction (11 (3.5%) vs. 22 (7.1%); 0.48 (CI 0.23–1.00); 0.04). did not reduce The outcomes non-cardiac needs confirmation appropriately powered randomised trials.